Response: Re: Clinical Factors Associated With Merkel Cell Polyomavirus Infection in Merkel Cell Carcinoma
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چکیده
منابع مشابه
Re: Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma.
Sihto et al. ( 1 ) recently analyzed 114 formalinfixed and paraffin-embedded Merkel cell carcinoma (MCC) samples from a Finnish cohort for the presence of Merkel cell polyomavirus (MCPyV) DNA. They reported that the prevalence of MCPyV DNA in MCC was 79.8% and, surprisingly, that MCPyV DNA – positive MCCs were preferentially located on the limbs compared with MCPyV DNA – negative MCCs. Their da...
متن کاملClinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma.
BACKGROUND Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown. METHODS We analyzed formalin-fixed paraffin-embedded Merkel cell carcinoma tissue samples from 114 of 207 patients diagnosed with Merkel cell carcinoma in Finland from ...
متن کاملmerkel cell polyomavirus infection in a patient with merkel cell carcinoma: a case report
conclusions the findings of this study are consistent with the hypothesis that local, systemic, or tumor-induced immunosuppression may allow the mcpyv to initiate skin aggressive cancer. it is necessary to maintain regular check over patients taking immunosuppressive medications for mcpyv infection. since there is not any information about detection and molecular biology analysis of mcpyv among...
متن کاملMerkel Cell Polyomavirus Strains in Patients with Merkel Cell Carcinoma
We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.
متن کاملMerkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma.
The majority of Merkel cell carcinomas (MCCs) are associated with the recently identified Merkel cell polyomavirus (MCV). However, as it is still unclear to which extent the presence of MCV impacts tumor characteristics or clinical outcome, we correlated the MCV status of tumor lesions obtained from 174 MCC patients including 38 MCC patients from Australia and 138 MCC patients from Germany with...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2009
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djp375